The 18S ribosomal RNA m6A methyltransferase Mettl5 is required for normal walking behavior in Drosophila
J Leismann, M Spagnuolo, M Pradhan, L Wacheul…�- EMBO�…, 2020 - embopress.org
RNA modifications have recently emerged as an important layer of gene regulation. N6‐
methyladenosine (m6A) is the most prominent modification on eukaryotic messenger RNA�…
methyladenosine (m6A) is the most prominent modification on eukaryotic messenger RNA�…
[HTML][HTML] CG14906 (mettl4) mediates m6A methylation of U2 snRNA in Drosophila
Dear Editor, While the eukaryotic candidate m6A methyltransferases belong to multiple
distinct methylase lineages, the most widespread group belongs to the MT-A70 family�…
distinct methylase lineages, the most widespread group belongs to the MT-A70 family�…
[HTML][HTML] Analysis of m6A RNA methylation in Caenorhabditis elegans
Dear Editor, One of the most abundant RNA modifications is N6-methyladenosine (m6A),
which is present in RNA from all forms of life, including viruses. This modification has been�…
which is present in RNA from all forms of life, including viruses. This modification has been�…
The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112
N Van Tran, FGM Ernst, BR Hawley…�- Nucleic acids�…, 2019 - academic.oup.com
Abstract N6-methyladenosine (m6A) has recently been found abundantly on messenger
RNA and shown to regulate most steps of mRNA metabolism. Several important m6A�…
RNA and shown to regulate most steps of mRNA metabolism. Several important m6A�…
The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs
VV Ignatova, P Stolz, S Kaiser…�- Genes &�…, 2020 - genesdev.cshlp.org
Covalent chemical modifications of cellular RNAs directly impact all biological processes.
However, our mechanistic understanding of the enzymes catalyzing these modifications�…
However, our mechanistic understanding of the enzymes catalyzing these modifications�…
Human METTL16 is a N6‐methyladenosine (m6A) methyltransferase that targets pre‐mRNAs and various non‐coding RNAs
AS Warda, J Kretschmer, P Hackert, C Lenz…�- EMBO�…, 2017 - embopress.org
Abstract N 6‐methyladenosine (m6A) is a highly dynamic RNA modification that has recently
emerged as a key regulator of gene expression. While many m6A modifications are installed�…
emerged as a key regulator of gene expression. While many m6A modifications are installed�…
Human m6A writers: Two subunits, 2 roles
Cellular RNAs with diverse chemical modifications have been observed, and N 6-
methyladenosine (m6A) is one of the most abundant internal modifications found on mRNA�…
methyladenosine (m6A) is one of the most abundant internal modifications found on mRNA�…
m6A deposition is regulated by PRMT1‐mediated arginine methylation of METTL14 in its disordered C‐terminal region
Abstract The N6‐methyladenosine (m6A) RNA modification serves crucial functions in RNA
metabolism; however, the molecular mechanisms underlying the regulation of m6A are not�…
metabolism; however, the molecular mechanisms underlying the regulation of m6A are not�…
METTL4 is an snRNA m6Am methyltransferase that regulates RNA splicing
Dear Editor, Protein coding mRNAs and non-coding RNAs are extensively modified by
chemical modifications, 1 including methylation of the N6 position of adenosine (m6A). 2�…
chemical modifications, 1 including methylation of the N6 position of adenosine (m6A). 2�…
The 18S rRNA m6A methyltransferase METTL5 promotes mouse embryonic stem cell differentiation
RNA modifications represent a novel layer of regulation of gene expression. Functional
experiments revealed that N6‐methyladenosine (m6A) on messenger RNA (mRNA) plays�…
experiments revealed that N6‐methyladenosine (m6A) on messenger RNA (mRNA) plays�…