Purpose.: Wound induced corneal fibrosis can lead to permanent visual impairment.
Keratocyte activation and differentiation play a key role in fibrosis, and vimentin, a major�…

Background: As one of the main blinding ocular diseases, corneal blindness resulted from
neovascularization that disrupts the angiogenic privilege of corneal avascularity. Following�…

Numerous studies have shown that fibroblasts play an important role in corneal wound
healing, however, the dynamic cellular events underlying wound tissue organization and�…

Corneal scarring is an obligatory consequence of stroma corneal injury and is a major cause
of decreased visual quality and vision loss worldwide. There are currently no satisfactory�…

Purpose.: Corneal injury may ultimately lead to a scar by way of corneal fibrosis, which is
characterized by the presence of myofibroblasts and improper deposition of extracellular�…

Corneal opacities affect vision for millions of individuals worldwide. Fibrotic scar tissues
accumulate in reaction to inflammatory responses and remain permanently in corneal�…

Purpose.: The mouse has become an important wound healing model with which to study
corneal fibrosis, a frequent complication of refractive surgery. The aim of the current study�…

Purpose.: Diabetic corneas overexpress proteinases including matrix metalloproteinase-10
(M10) and cathepsin F (CF). Our purpose was to assess if silencing M10 and CF in organ�…

Corneal fibrosis (or scarring) occurs in response to ocular trauma or infection, and by
reducing corneal transparency, it can lead to visual impairment and blindness. Studies�…

The cornea has been used extensively as a model system to study wound healing. The
ability to generate and utilize primary mammalian cells in two dimensional (2D) and three�…