Fragile X syndrome (FXS) is an inherited intellectual impairment that results from the loss of
fragile X mental retardation protein (FMRP), an mRNA binding protein that regulates mRNA�…

Amyloid precursor protein (APP) facilitates synapse formation in the developing brain, while
beta-amyloid (Aβ) accumulation, which is associated with Alzheimer disease, results in�…

The proteome of glutamatergic synapses is diverse across the mammalian brain and
involved in neurodevelopmental disorders (NDDs). Among those is fragile X syndrome�…

How the loss of fragile X mental retardation protein (FMRP) in different brain cell types,
especially in non-neuron glial cells, induces fragile X syndrome (FXS) phenotypes has just�…

The salient neuropathological defect in fragile X syndrome is the overabundance of
immature dendritic spines in cortical pyramidal neurons. This review examines this�…

Abstract The Fragile X syndrome (FXS) is a leading cause of intellectual disability (ID) and
autism. The disease is caused by mutations or loss of the Fragile X Mental Retardation�…

Fragile X syndrome (FXS) is the most common identifiable genetic cause of intellectual
disability and autistic spectrum disorders (ASD), with up to 50% of males and some females�…

The Fragile X syndrome, which results from the absence of functional FMRP protein, is the
most common heritable form of mental retardation. Here, we show that FMRP acts as a�…

Fragile X syndrome (FraX), caused by the loss-of-function of one gene (FMR1), is the most
common inherited form of both mental retardation and autism spectrum disorders. The FMR1�…

Genetic deletion of fragile X mental retardation protein (FMRP) has been shown to enhance
mGluR-dependent long-term depression (LTD). Herein, we demonstrate that mGluR-LTD�…