Group 1 metabotropic glutamate receptor (mGluR)-stimulated protein synthesis and long-
term synaptic depression (mGluR-LTD) are altered in the mouse model of fragile X�…

Fragile X syndrome, a common form of inherited mental retardation, is caused by the loss of
fragile X mental retardation protein (FMRP), an mRNA binding protein that is hypothesized�…

Fragile X syndrome (FXS) is a common inherited cause of mental retardation resulting from
the absence of the fragile X mental retardation protein (FMRP). FMRP is thought to regulate�…

Abstract Background Fragile X syndrome (FXS) is caused by the absence of the mRNA-
binding protein Fragile X mental retardation protein (FMRP), encoded by the Fmr1 gene�…

Fragile X Syndrome (FXS), the most common inherited form of intellectual disability, is
caused by loss of the fragile X mental retardation protein (FMRP). FMRP is a negative�…

Abstract The Fragile X Mental Retardation Protein (FMRP) is an RNA-binding protein
essential to the regulation of local translation at synapses. In the mammalian brain�…

Fragile X syndrome, the most common form of inherited mental retardation and leading
genetic cause of autism, is caused by transcriptional silencing of the Fmr1 gene. The fragile�…

Loss of the mRNA-binding protein FMRP results in the most common inherited form of both
mental retardation and autism spectrum disorders: fragile X syndrome (FXS). The leading�…

Many of the diverse functional consequences of activating group 1 metabotropic glutamate
receptors require translation of pre-existing mRNA near synapses. One of these�…

Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by the loss-of-function
of fragile X mental retardation protein (FMRP). The loss of FMRP function in neurons�…