Metabotropic glutamate receptors and fragile x mental retardation protein: partners in translational regulation at the synapse
JA Ronesi, KM Huber�- Science signaling, 2008 - science.org
Fragile X syndrome (FXS) mental retardation is caused by loss-of-function mutations in an
RNA-binding protein, fragile X mental retardation protein (FMRP). Previous studies in�…
RNA-binding protein, fragile X mental retardation protein (FMRP). Previous studies in�…
Metabotropic receptor-dependent long-term depression persists in the absence of protein synthesis in the mouse model of fragile X syndrome
ED Nosyreva, KM Huber�- Journal of neurophysiology, 2006 - journals.physiology.org
Fragile X syndrome (FXS), a form of human mental retardation, is caused by loss of function
mutations in the fragile X mental retardation gene (FMR1). The protein product of FMR1�…
mutations in the fragile X mental retardation gene (FMR1). The protein product of FMR1�…
The pathophysiology of fragile X (and what it teaches us about synapses)
Fragile X is the most common known inherited cause of intellectual disability and autism,
and it typically results from transcriptional silencing of FMR1 and loss of the encoded�…
and it typically results from transcriptional silencing of FMR1 and loss of the encoded�…
Fragile X mental retardation protein induces synapse loss through acute postsynaptic translational regulation
BE Pfeiffer, KM Huber�- Journal of neuroscience, 2007 - Soc Neuroscience
Fragile X syndrome, as well as other forms of mental retardation and autism, is associated
with altered dendritic spine number and structure. Fragile X syndrome is caused by loss-of�…
with altered dendritic spine number and structure. Fragile X syndrome is caused by loss-of�…
[HTML][HTML] Sunrise at the synapse: the FMRP mRNP shaping the synaptic interface
LN Antar, GJ Bassell�- Neuron, 2003 - cell.com
Recent studies provide new insight into the mechanistic function of Fragile X Mental
Retardation Protein (FMRP), paving the way to understanding the biological basis of Fragile�…
Retardation Protein (FMRP), paving the way to understanding the biological basis of Fragile�…
FMRP phosphorylation reveals an immediate-early signaling pathway triggered by group I mGluR and mediated by PP2A
U Narayanan, V Nalavadi, M Nakamoto…�- Journal of�…, 2007 - Soc Neuroscience
Fragile X syndrome is a common form of inherited mental retardation and is caused by loss
of fragile X mental retardation protein (FMRP), a selective RNA-binding protein that�…
of fragile X mental retardation protein (FMRP), a selective RNA-binding protein that�…
Hypersensitivity to mGluR5 and ERK1/2 leads to excessive protein synthesis in the hippocampus of a mouse model of fragile X syndrome
EK Osterweil, DD Krueger, K Reinhold…�- Journal of�…, 2010 - Soc Neuroscience
Fragile X syndrome (FXS) is caused by loss of the FMR1 gene product FMRP (fragile X
mental retardation protein), a repressor of mRNA translation. According to the metabotropic�…
mental retardation protein), a repressor of mRNA translation. According to the metabotropic�…
From FMRP function to potential therapies for fragile X syndrome
Fragile X syndrome (FXS) is caused by mutations in the fragile X mental retardation 1
(FMR1) gene. Most FXS cases occur due to the expansion of the CGG trinucleotide repeats�…
(FMR1) gene. Most FXS cases occur due to the expansion of the CGG trinucleotide repeats�…
Metabotropic glutamate receptor activation regulates fragile x mental retardation protein and FMR1 mRNA localization differentially in dendrites and at synapses
LN Antar, R Afroz, JB Dictenberg…�- Journal of�…, 2004 - Soc Neuroscience
Fragile X syndrome is caused by the absence of the mRNA-binding protein Fragile X mental
retardation protein (FMRP), which may play a role in activity-regulated localization and�…
retardation protein (FMRP), which may play a role in activity-regulated localization and�…
[HTML][HTML] Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function
GJ Bassell, ST Warren�- Neuron, 2008 - cell.com
Fragile X syndrome is the most common inherited form of cognitive deficiency in humans
and perhaps the best-understood single cause of autism. A trinucleotide repeat expansion�…
and perhaps the best-understood single cause of autism. A trinucleotide repeat expansion�…