Embryonic intraventricular exposure to autism-specific maternal autoantibodies produces alterations in autistic-like stereotypical behaviors in offspring mice
J Camacho, K Jones, E Miller, J Ariza, S Noctor…�- Behavioural brain�…, 2014 - Elsevier
Multiple studies have implicated a role of maternal autoantibodies reactive against fetal
brain proteins specific to autism in the etiology of autism spectrum disorders (ASD). In the�…
brain proteins specific to autism in the etiology of autism spectrum disorders (ASD). In the�…
Autism-specific maternal autoantibodies produce behavioral abnormalities in an endogenous antigen-driven mouse model of autism
KL Jones, MC Pride, E Edmiston, M Yang…�- Molecular�…, 2020 - nature.com
Immune dysregulation has been noted consistently in individuals with autism spectrum
disorder (ASD) and their families, including the presence of autoantibodies reactive to fetal�…
disorder (ASD) and their families, including the presence of autoantibodies reactive to fetal�…
Prenatal exposure to autism-specific maternal autoantibodies alters proliferation of cortical neural precursor cells, enlarges brain, and increases neuronal size in adult�…
V Mart�nez-Cerde�o, J Camacho, E Fox, E Miller…�- Cerebral�…, 2016 - academic.oup.com
Autism spectrum disorders (ASDs) affect up to 1 in 68 children. Autism-specific
autoantibodies directed against fetal brain proteins have been found exclusively in a�…
autoantibodies directed against fetal brain proteins have been found exclusively in a�…
Maternal autism-associated IgG antibodies delay development and produce anxiety in a mouse gestational transfer model
D Braunschweig, MS Golub, CM Koenig, L Qi…�- Journal of�…, 2012 - Elsevier
A murine passive transfer model system was employed to ascertain the effects of gestational
exposure to a single, intravenous dose of purified, brain-reactive IgG antibodies from�…
exposure to a single, intravenous dose of purified, brain-reactive IgG antibodies from�…
Prenatal exposure to antibodies from mothers of children with autism produces neurobehavioral alterations: a pregnant dam mouse model
HS Singer, C Morris, C Gause, M Pollard…�- Journal of�…, 2009 - Elsevier
A pregnant mouse model was used to compare the effect of IgG, administered E13-E18,
from mothers of children with autistic disorder (MCAD), to controls (simple-and IgG-) on�…
from mothers of children with autistic disorder (MCAD), to controls (simple-and IgG-) on�…
[HTML][HTML] Maternal antibodies from mothers of children with autism alter brain growth and social behavior development in the rhesus monkey
Antibodies directed against fetal brain proteins of 37 and 73 kDa molecular weight are found
in approximately 12% of mothers who have children with autism spectrum disorder (ASD)�…
in approximately 12% of mothers who have children with autism spectrum disorder (ASD)�…
[HTML][HTML] Altered behavior, brain structure, and neurometabolites in a rat model of autism-specific maternal autoantibody exposure
MR Bruce, ACM Couch, S Grant, J McLellan, K Ku…�- Molecular�…, 2023 - nature.com
Maternal immune dysregulation is a prenatal risk factor for autism spectrum disorder (ASD).
Importantly, a clinically relevant connection exists between inflammation and metabolic�…
Importantly, a clinically relevant connection exists between inflammation and metabolic�…
Altered postnatal cell proliferation in brains of mouse pups prenatally exposed to IgG from mothers of children with autistic disorder
SD Kadam, BM French, ST Kim…�- Journal of�…, 2013 - journals.sagepub.com
Auto antibodies found in the mothers of children with autistic disorder (MCAD) when
passively transferred to pregnant mice cause behavioral alterations in juvenile and adult�…
passively transferred to pregnant mice cause behavioral alterations in juvenile and adult�…
Autism: maternally derived antibodies specific for fetal brain proteins
D Braunschweig, P Ashwood, P Krakowiak…�- Neurotoxicology, 2008 - Elsevier
Autism is a profound disorder of neurodevelopment with poorly understood biological
origins. A potential role for maternal autoantibodies in the etiology of some cases of autism�…
origins. A potential role for maternal autoantibodies in the etiology of some cases of autism�…
Maternal autoantibodies are associated with abnormal brain enlargement in a subgroup of children with autism spectrum disorder
Autism spectrum disorder (ASD) is very heterogeneous and multiple subtypes and etiologies
likely exist. The maternal immune system has been implicated in the pathogenesis of some�…
likely exist. The maternal immune system has been implicated in the pathogenesis of some�…