The discovery of the genetic causes of syndromic autism spectrum disorders and intellectual
disabilities has greatly informed our understanding of the molecular pathways critical for …

… disorders require a more personalized treatment regimen. Many ASD risk factors are
genetic, implicating impaired synaptic development and function. Monogenetic disorders (eg, …

… linked to synapse dysfunction can broadly be separated in three categories: disorders of
transcriptional regulation, disorders of synaptic signaling and disorders of synaptic scaffolding …

… of synaptic dysfunction of … synapses. In this review, we focus on NMDARs (Table 1) and
NLGNs (Table 2), to explore mechanisms that converge on glutamatergic synaptic dysfunction. …

… suitable models for investigating alterations in individuals with neurodevelopmental
disorders [89]. Organoids have been used in the study of lissencephaly, a genetic neurological …

… In a mouse model of Rett syndrome, a neurodevelopmental disorder caused by mutations
in MECP2, synapse engulfment by microglia was found to be excessive compared with control …

… disorders, which is not surprising considering their crucial role in … neurodevelopmental
disorders as a continuum of pathological manifestations, suggesting that glutamatergic synapses …

… for NDDs, among which synaptic genes represent the most … by synaptic dysfunctions, here
we use the term Synaptopathies as the class of diseases caused by modifications in synaptic …

… , we will review central aspects of synapse dysfunction in prevalent neurodevelopmental
and neurodegenerative disorders. Synapse dysfunction in neurodevelopmental disorders …

… Mounting evidence has shown a link to inhibitory synapse … We discuss common ribs of
inhibitory synapse dysfunction in … Increasing our basic understanding of inhibitory synapses, …