… of syndromic autism spectrum disorders and intellectual disabilities has greatly informed
our understanding of the molecular pathways critical for normal synaptic function. The top-down …

Intellectual disability (ID) is a common and highly heterogeneous paediatric disorder with a
very severe social impact. Intellectual disability can be caused by environmental and/or …

… also manifest severe intellectual disability. Though certain … and discusses the crucial role
synaptic activity plays in proper … able to counteract functional synaptic anomalies and potentially …

… encoded intellectual disabilities (ID). Yet, more than 100 human X-linked genes – and several
hundreds of autosomal genes - have been associated with ID in humans. These mutations …

… intellectual disability has identified, over the past twenty years, numerous mutated genes that
code for proteins concerned with synapse … responsible for intellectual disability syndromes. …

… intellectual disability (ID). It is caused by a mutation in the FMR1 gene that encodes the
Fragile X mental retardation protein (FMRP), which regulates trafficking, stability, and translation …

… Recent remarkable progress, which allows to establish consistent correlations between
deregulation of well-known signaling pathways and synaptic dysfunction, should open …

… Spine dysgenesis was one of the earliest biological findings in intellectual disability patients
[34], accompanied by dendritic abnormalities in cortical pyramidal neurons in these patients […

… synergy among these synaptic components is defined as “… with cognitive disturbances/intellectual
disability, autistic features, and … presenting with epilepsy and intellectual disability (ID). …

… of major synaptic proteins or the synaptic actin cytoskeleton assembly or disassembly. In
this review we will describe some molecular mechanisms by which dysfunctions in several of …