… that the entire NDRG1 protein is highly … the mutation that causes polyneuropathy in Alaskan
Malamutes. Our characterization of a novel candidate causative mutation for polyneuropathy …

… to be homozygous for a mutation in the N-myc downstream-regulated gene 1 (NDRG1) [4]. …
They were clinically diagnosed with AM polyneuropathy, as described by Bruun et al. [4]. …

… investigated Alaskan Malamute dogs with neuropathy caused … neuropathies caused by
mutations in N-myc downstream-… Gly98Val) [3]. Clinically, the disease is slowly progressive and …

… The N-myc downstream-regulated gene 1 (NDRG1) was first … Alaskan malamute dog
homozygous for a disease-causing Gly98Val mutation in NDRG1 (hereafter called NDRG1 mut/mut …

… ) had been tested for NDRG1 (Gly98Val; Exon 4) previously. … to polyneuropathy in breeds
such as the Alaskan Malamute 6 … tested negative for the Alaskan Malamute mutation. This is …

… with a mutation of N-myc downstream-regulated gene 1 (NDRG1) responsible … a Gly98Val
mutation of NDRG1 associated to a polyneuropathy has been reported in Alaskan Malamutes …

… CNV of NDRG1 causing hereditary motor and sensory neuropathy-… R361SerfsX60) and a
single-nucleotide variant mutation (… and Alaskan Malamute pedigrees with polyneuropathy. AR …

… -associated gene (NDRG1) in Greyhounds [6] and Alaskan Malamute … one copy of the GJA9
mutant allele to determine age of onset and penetrance of the mutant allele (Additional file 1…

… of 3 to 19 months for the Alaskan malamute; between 3 and 9 months … mutations were
identified in the NDRG1 gene (N-myc downstream regulated 1): a G–T point mutation for Alaskan …

… ] and Alaskan Malamutes [8] with early-onset polyneuropathy … -onset peripheral neuropathies
with a known genetic basis in … recessive conditions due to mutations in the NDRG1 gene [7]…