Subcortical brain alterations in carriers of genomic copy number variants
Objective: Copy number variants (CNVs) are well-known genetic pleiotropic risk factors for
multiple neurodevelopmental and psychiatric disorders (NPDs), including autism (ASD) and�…
multiple neurodevelopmental and psychiatric disorders (NPDs), including autism (ASD) and�…
[HTML][HTML] Integrative omics analysis reveals epigenomic and transcriptomic signatures underlying brain structural deficits in major depressive disorder
Several lines of evidence support the involvement of transcriptomic and epigenetic
mechanisms in the brain structural deficits of major depressive disorder (MDD) separately�…
mechanisms in the brain structural deficits of major depressive disorder (MDD) separately�…
Transcriptional substrates of brain structural and functional impairments in drug-naive first-episode patients with major depressive disorder
Q Fang, H Cai, P Jiang, H Zhao, Y Song, W Zhao…�- Journal of Affective�…, 2023 - Elsevier
Background Despite remarkable success in identifying genetic risk factors for depression,
there are still open questions about the exact genetic mechanisms underlying certain�…
there are still open questions about the exact genetic mechanisms underlying certain�…
Structural and functional brain alterations revealed by neuroimaging in CNV carriers
Copy Number Variants (CNVs) are associated with elevated rates of neuropsychiatric
disorders. A 'genetics-first'approach, involving the CNV effects on the brain, irrespective of�…
disorders. A 'genetics-first'approach, involving the CNV effects on the brain, irrespective of�…
Morphological and genetic decoding shows heterogeneous patterns of brain aging in chronic musculoskeletal pain
Chronic musculoskeletal pain (CMP), a prevalent and heterogeneous condition
characterized by persistent pain in various body parts, is a leading cause of disability�…
characterized by persistent pain in various body parts, is a leading cause of disability�…
Sexually divergent development of depression-related brain networks during healthy human adolescence
Sexual differences in human brain development could be relevant to sex differences in the
incidence of depression during adolescence. We tested for sex differences in parameters of�…
incidence of depression during adolescence. We tested for sex differences in parameters of�…
[HTML][HTML] Longitudinal development of the human white matter structural connectome and its association with brain transcriptomic and cellular architecture
G Feng, R Chen, R Zhao, Y Li, L Ma, Y Wang…�- Communications�…, 2023 - nature.com
From childhood to adolescence, the spatiotemporal development pattern of the human brain
white matter connectome and its underlying transcriptomic and cellular mechanisms remain�…
white matter connectome and its underlying transcriptomic and cellular mechanisms remain�…
Clinically feasible brain morphometric similarity network construction approaches with restricted magnetic resonance imaging acquisitions
Morphometric similarity networks (MSNs) estimate organization of the cortex as a
biologically meaningful set of similarities between anatomical features at the macro-and�…
biologically meaningful set of similarities between anatomical features at the macro-and�…
Gene expression has distinct associations with brain structure and function in major depressive disorder
Major depressive disorder (MDD) is associated with structural and functional brain
abnormalities. MDD as well as brain anatomy and function are influenced by genetic factors�…
abnormalities. MDD as well as brain anatomy and function are influenced by genetic factors�…
[HTML][HTML] Network connectivity and local transcriptomic vulnerability underpin cortical atrophy progression in Parkinson's disease
Parkinson's disease pathology is hypothesized to spread through the brain via axonal
connections between regions and is further modulated by local vulnerabilities within those�…
connections between regions and is further modulated by local vulnerabilities within those�…