Depression is a serious public health problem, and adolescence is an 'age of risk'for the
onset of Major Depressive Disorder. Recently, we and others have proposed neuroimmune�…

Crosstalk between inflammatory pathways and neurocircuits in the brain can lead to
behavioural responses, such as avoidance and alarm, that are likely to have provided early�…

Current diagnosis of depression is based solely on behavioral symptomatology. The
available US Food and Drug Administration–approved treatments for depression have come�…

Children who experience chronic stressors are vulnerable to emotional and physical health
problems across the lifespan. This phenomenon raises questions for scientists and�…

Background Depression is associated with a reduced sensitivity to rewards and low reward-
related brain function in cortico-striatal circuitry. A separate literature documents elevated�…

Early-life stress is associated with increased vulnerability to physical and emotional health
problems across the lifespan. The recently developed neuroimmune network hypothesis�…

There are several hypotheses concerning the underlying pathophysiological mechanisms of
major depression, which centre largely around adaptive changes in neuronal transmission�…

Disruptions in stress-sensitive biological systems, notably the immune system and
hypothalamic-pituitary-adrenal axis, are strongly implicated in depression, and disturbances�…

Since the inception of Brain, Behavior and Immunity twenty years ago, many exciting
developments have occurred regarding the relationship between depression and the�…

Extensive research suggests a role for the innate immune system in the pathogenesis of
depression, but most of the studies are conducted in adult populations, in high-income�…