… Spinal cord involvement was first recognised in the 1960s when post-mortem autopsy studies
in patients with advanced diabetes … painful diabetic peripheral neuropathy phenotype. R …

… Alterations in the spinal cord were first demonstrated in postmortem and somatosensory …
role of supraspinal plasticity involving the thalamus following peripheral nerve injury in diabetes …

… Diabetic peripheral neuropathy (DPN) is the most common … cross-sectional area of the spinal
cord in patients with subclinical-DPN … our knowledge of the early cerebral changes in DPN. …

… Due to its early involvement, detection of small fiber damage is important for the early
diagnosis of neuropathy and for the prevention of further progression. Numerous testing methods …

… role in the development of diabetic peripheral neuropathy, strict glycemic control does not
eliminate the risk of diabetic peripheral neuropathy. … extent of spinal cord involvement early in …

… active nociceptors into the spinal cord, which enhances synaptic … synaptic signaling within
the spinal cord and contribute to … DM onset, subclinical involvement can be detected as early …

… this is the first study to indicate higher cortical energy metabolism in painful compared with
painless diabetic peripheral neuropathy, and thus has the potential to act as a biomarker for …

… The delayed manifestation of diabetic neuropathy (DN) makes early diagnosis challenging,
… a crucial role in the pathogenic signals of DN. In peripheral nerves and the spinal cord of …

… of nociceptive transmission at the spinal cord. Changes in … First, we have to confirm that leg
pain is due to neuropathy (… treatment of painful diabetic neuropathies (Ziegler et al 2006, El-…

… found to reverse the diabetic peripheral neuropathic pain in rats … the role of AT1 rather than
AT2 in diabetic neuropathic pain (… the role of Losartan in countering diabetic neuropathic pain …