Structural and functional reorganization of inhibitory synapses by activity-dependent cleavage of neuroligin-2

N Xu, R Cao, SY Chen, XZ Gou…�- Proceedings of the�…, 2024 - National Acad Sciences
… or proteolytically cleavage of engineered LRRTM2 that does not undergo proteolytic cleavage
… of nanocolumns in glutamatergic synapses, including neuroligin-1 (13), neuroligin-3 (12), …

[HTML][HTML] Neuronal SAM68 differentially regulates alternative last exon splicing and ensures proper synapse development and function

…, M Ito, Y Iijima, A Takase, N Ayukawa, S Suzuki…�- Journal of Biological�…, 2023 - ASBMB
… SAM68 regulates neuronal activity-dependent ALE isoform selections of Pcdh15 … Our
previous study has demonstrated that SAM68 regulates neuronal activity-dependent alternative …

A multi-faceted analysis of synapses reveals the role of neuroligin-1 cleavage in presynaptic vesicle accumulation in the lateral amygdala

CI Thomas, JR Anderson, A Alexis, D Guerrero-Given…�- bioRxiv, 2023 - biorxiv.org
… Understanding the role of NLGN1 cleavage in vivo and in … of activity dependent cleavage
of CAMs by proteases and its … cleavage by proteases occurs, the role of this cleavage and …

Soluble form of Lingo2, an autism spectrum disorder-associated molecule, functions as an excitatory synapse organizer in neurons

T Tomita, F Yoshida, R Nagatomo, M Kimura, S Shun… - 2023 - researchsquare.com
… The secreted form of the extracellular domain of Lingo2 (sLingo2) is produced by the
transmembrane metalloprotease ADAM10 through proteolytic processing. sLingo2 was found to …

Glutamate signaling and neuroligin/neurexin adhesion play opposing roles that are mediated by major histocompatibility complex I molecules in cortical synapse�…

GL Sell, SL Barrow, AK McAllister�- bioRxiv, 2024 - biorxiv.org
… following initial axodendritic contact 21 via a neuroligin 1 (NL1) -dependent mechanism 22,…
the synapse that cause synapse loss in an activity-dependent manner may play a role. MHCI …

[HTML][HTML] Multiple N-linked glycosylation sites critically modulate the synaptic abundance of neuroligin isoforms

O Benner, TP Cast, LS Minamide, Z Lenninger…�- Journal of Biological�…, 2023 - ASBMB
In recent years, elegant glycomic and glycoproteomic approaches have revealed an intricate
glycosylation profile of mammalian brain with enormous spatial and temporal diversities. …

Turnover of synaptic adhesion molecules

M Nabavi, PR Hiesinger�- Molecular and Cellular Neuroscience, 2023 - Elsevier
… , the effects of activity-dependent turnover of synaptic adhesion … Activity-dependent changes
to dendritic spines of … exo−/endocytosis, proteolytic cleavage, or modulation of constitutively …

Isolation of the Brain Secretome from Ex Vivo Brain Slice Cultures

C Du, H Ou, J Lu�- JoVE (Journal of Visualized Experiments), 2023 - jove.com
… The brain secretome consists of proteins either actively secreted or shed from the cell
surface by proteolytic cleavage in the extracellular matrix of the nervous system. These proteins …

[HTML][HTML] The CHD family chromatin remodeling enzyme, Kismet, promotes both clathrin-mediated and activity-dependent bulk endocytosis

EL Hendricks, FLW Liebl�- Plos one, 2024 - journals.plos.org
… also modulates endocytosis as null mutations in Neuroligin 1 (Nlg1) enhance endocytosis …
(Aβ) plaques, which are produced by proteolytic cleavage of amyloid precursor protein (APP) […

Nuclear access of DNlg3 c-terminal fragment and its function in regulating innate immune response genes

H Xie, S Liu, Y Fu, Q Cheng, P Wang, CL Bi…�- Biochemical and�…, 2023 - Elsevier
… Several interesting reports have shown that the proteolytic cleavage maybe a prominent …
domain [5,17,18] are subjected to an activity-dependent cleavage, both in vivo and in vitro [19,20…