… In recent years, researchers have found that neuroligin can be hydrolyzed by various
proteases at different stages of development, neuronal activities or pathological states of some …

… activity-dependent proteolytic processing [17, 18]. Specifically, the NL1 protein on the cell
surface is cleaved by … This cleavage of NL1 determines the cell-surface level of functional NL1, …

… or proteolytically cleavage of engineered LRRTM2 that does not undergo proteolytic cleavage
… of nanocolumns in glutamatergic synapses, including neuroligin-1 (13), neuroligin-3 (12), …

… ) (Peixoto et al., 2012; Suzuki et al., 2012). In contrast, ADAM10 claves Nlgn3 under basal
condition and activity-dependent cleavage of Nlgn3 is mediated by metabotropic glutamate …

… Neuroligin 1 (NLGN1) is a transmembrane protein that interacts at the synapse with the
tumor suppressor adenomatous polyposis Coli (APC), which is heavily involved in the …

… Cleaved proteins are indicated next to their main protease; however, each substrate can be
cleaved by multiple proteases. … wild-type ectodomain is processed by activity-dependent ES [ …

… SAM68 regulates neuronal activity-dependent ALE isoform selections of Pcdh15 … Our
previous study has demonstrated that SAM68 regulates neuronal activity-dependent alternative …

… Nlgn1 extracellular domain undergoes proteolytic cleavage near to … This ectodomain
shedding appears to be activity-dependent, thus … AD patients met the 2012 NIA-AA guidelines for …

… Understanding the role of NLGN1 cleavage in vivo and in … of activity dependent cleavage
of CAMs by proteases and its … cleavage by proteases occurs, the role of this cleavage and …

… In addition to activity-dependent cleavage, NL1 has also been shown to undergo
phosphorylation specifically at T793 by CamKII in vitro and in vivo. In cultured cortical neurons, NL1 …