Published May 14, 2021 | Version 1
Software Open

Code for Estimation of Parameters for an Archetypal Model of Cardiomyocyte Membrane Potentials

Creators

  • 1. Institute of Mathematical Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur
  • 2. School of Mathematics and Statistics, University of Glasgow, Glasgow G12 8QQ, UK

Description

This is a suite of MATLAB/Octave functions for numerical solution of and for estimation of the parameter values of the cardiomyocyte membrane potential model of Biktashev et al. (Bull Math Biol, 70(2), 2008,doi:10.1007/s11538-007-9267-0) - "the archetypal model". In particular, the code can be used determine parameter values for the archetypal model such that its solutions approximate the action potential traces and the action potential duration restitution curves of (a) other electrophysiologically detailed mathematical models of the transmembrane ionic currents of single cardiac myocytes - "target models", as well as (b) traces and curves measured experimentally - "target data".

Data and functions for several detailed ionic models from the CellML physiological model repository (cellml.org) are included as examples of usage.

Notes

This work was supported by the UK Engineering and Physical Sciences Research Council [EPSRC grant numbers EP/N014642/1, EP/S030875/1, EP/T017899/1]. M.H.N. Aziz was funded by Ministry of Higher Education Malaysia and University of Malaya under a SLAB scholarship.

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ParamEstimation.zip

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Additional details

Related works

Is supplement to
Journal article: http://arxiv.org/abs/2105.06853 (URL)