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Task-free presurgical mapping using functional magnetic resonance imaging intrinsic activity

Laboratory investigation

Hesheng Liu Massachusetts General Hospital/Massachusetts Institute of Technology/Harvard Medical School Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Charlestown;

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 Ph.D.
,
Randy L. Buckner Massachusetts General Hospital/Massachusetts Institute of Technology/Harvard Medical School Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Charlestown;
Harvard University Department of Psychology, Center for Brain Science, Cambridge;
Howard Hughes Medical Institute, Chevy Chase, Maryland

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 Ph.D.
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Tanveer Talukdar Massachusetts General Hospital/Massachusetts Institute of Technology/Harvard Medical School Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Charlestown;
Harvard University Department of Psychology, Center for Brain Science, Cambridge;

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 M.S.
,
Naoaki Tanaka Massachusetts General Hospital/Massachusetts Institute of Technology/Harvard Medical School Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Charlestown;

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 M.D.
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Joseph R. Madsen Children's Hospital, Boston, Massachusetts; and

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 M.D.
, and
Steven M. Stufflebeam Massachusetts General Hospital/Massachusetts Institute of Technology/Harvard Medical School Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Charlestown;
Massachusetts Institute of Technology-Harvard Division of Health Sciences and Technology, Cambridge;

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Page Range:
746–754
Volume/Issue:
Volume 111: Issue 4
DOI link:
https://doi.org/10.3171/2008.10.JNS08846
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Object

Low-frequency components of the spontaneous functional MR imaging signal provide information about the intrinsic functional and anatomical organization of the brain. The ability to use such methods in individual patients may provide a powerful tool for presurgical planning. The authors explore the feasibility of presurgical motor function mapping in which a task-free paradigm is used.

Methods

Six surgical candidates with tumors or epileptic foci near the motor cortex participated in this study. The investigators directly compared task-elicited activation of the motor system to activation obtained from intrinsic activity correlations. The motor network within the unhealthy hemisphere was identified based on intrinsic activity correlations, allowing distortions of functional anatomy caused by the tumor and epilepsy to be directly visualized. The precision of the motor function mapping was further explored in 1 participant by using direct cortical stimulation.

Results

The motor regions localized based on the spontaneous activity correlations were quite similar to the regions defined by actual movement tasks and cortical stimulation. Using intrinsic activity correlations, it was possible to map the motor cortex in presurgical patients.

Conclusions

This task-free paradigm may provide a powerful approach to map functional anatomy in patients without task compliance and allow multiple brain systems to be determined in a single scanning session.

Abbreviations used in this paper:

fcMR = functional connectivity MR ; fMR = functional MR .
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Contributor Notes

Address correspondence to: Steven M. Stufflebeam, M.D., Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Building 149, 13th Street, Charlestown, Massachusetts 02129. email:sms@nmr.mgh.harvard.edu.

Please include this information when citing this paper: published online April 10, 2009; DOI: 10.3171/2008.10.JNS08846.

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