Abstract
Trial-to-trial variability in the blood oxygen level–dependent (BOLD) response of functional magnetic resonance imaging has been shown to be relevant to human perception and behavior, but the sources of this variability remain unknown. We demonstrate that coherent spontaneous fluctuations in human brain activity account for a significant fraction of the variability in measured event-related BOLD responses and that spontaneous and task-related activity are linearly superimposed in the human brain.
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Acknowledgements
This work was supported by the US National Institutes of Health grant NS06833.
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Supplementary information
Supplementary Fig. 1
Reproduction of figure 2 from the article for each of the 14 subjects. (PDF 2423 kb)
Supplementary Table 1
Regional statistics for each subject (PDF 60 kb)
Supplementary Table 2
Changes in signal power, noise power, and signal/noise ratio for LMC event-related responses upon removal of RMC activity for each subject (PDF 52 kb)
Supplementary Table 3
Response magnitudes binned by activity in the right somatomotor cortex. (PDF 56 kb)
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Fox, M., Snyder, A., Zacks, J. et al. Coherent spontaneous activity accounts for trial-to-trial variability in human evoked brain responses. Nat Neurosci 9, 23–25 (2006). https://doi.org/10.1038/nn1616
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DOI: https://doi.org/10.1038/nn1616
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