Abstract
Although autism spectrum disorders (ASD) affect more males than females, it is not clear whether neurobehavioural correlates of ASD are equivalent across genders. This study examined gender differences in neurobehavioural functioning in boys and girls with ASD. Participants were males with ASD (n = 10), females with ASD (n = 13), typically developing males (n = 8), and typically developing females (n = 14). Each completed the stop task, a common measure of response inhibition. Females with ASD demonstrated a significant increase in stopping time (indicating poorer inhibition). By contrast, no response inhibition impairments were evident among males with ASD. Females with ASD may have a different neurobehavioural profile, and therefore different clinical needs, when compared with males with ASD.
References
American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders—Text revision (4th ed.). Washington, DC: American Psychiatric Association Press.
Attwood, A. (2007). The complete guide to Asperger’s syndrome. Philadelphia: Jessica Kingsley Publishers.
Barkley, R. A. (1997). Behavioural inhibition, sustained attention, and executive functions: Constructing a unifying theory of ADHD. Psychological Bulletin, 121(1), 65–94.
Bryson, S. E., Clark, B. S., & Smith, I. M. (1988). First report of a Canadian epidemiological study of autistic syndromes. Journal of Child Psychology and Psychiatry, 29(4), 433–445.
Carter, A. S., Black, D. O., Tewani, S., Connolly, C. E., Kadlec, M. B., & Tager-Flusberg, H. (2007). Sex differences in toddlers with autism spectrum disorders. Journal of Autism and Developmental Disorders, 37(1), 86–97.
Carter, J. D., Farrow, M., Silberstein, R. B., Stough, C., Tucker, A., & Pipingas, A. (2003). Assessing inhibitory control: A revised approach to the stop signal task. Journal of Attentional Disorders, 6, 153–161.
Christ, S. E., Holt, D. D., White, D. A., & Green, L. (2007). Inhibitory control in children with autism spectrum disorder. Journal of Autism and Developmental Disorders, 37(6), 1155–1165.
Denckla, M. B. (1996). A theory and model of executive function: A neurological perspective. In G. R. Lyon & N. A. Krasnegor (Eds.), Attention, memory, and executive function (pp. 263–278). Baltimore, MD: Paul H. Brookes Publishing Co.
Einfeld, S. L., & Tonge, B. T. (2002). Manual for the developmental behaviour checklist (second edition)—primary carer version (DBC-P) and teacher version (DBC-T). Melbourne and Sydney: Monash University Centre for Developmental Psychiatry & Psychology and School of Psychiatry, University of New South Wales.
Enticott, P. G., Bradshaw, J. L., Bellgrove, M. A., Upton, D. J., & Ogloff, J. R. P. (2009). Stop task after-effects: The extent of slowing during the preparation and execution of movement. Experimental Psychology, 56(4), 247–251.
Enticott, P. G., Ogloff, J. R. P., & Bradshaw, J. L. (2006). Associations between laboratory measures of executive inhibitory control and self-reported impulsivity. Personality and Individual Differences, 41(2), 285–294.
Enticott, P. G., Ogloff, J. R. P., & Bradshaw, J. L. (2008). Response inhibition and impulsivity in schizophrenia. Psychiatry Research, 157(1–3), 251–254.
Faherty, C. (2006). Asperger’s syndrome in women: A different set of challenges? In Asperger’s and girls. Arlington, TX: Future Horizons.
Gaub, M., & Carlson, C. L. (1997). Gender differences in ADHD: A meta-analysis and critical review. Journal of the American Academy of Child and Adolescent Psychiatry, 36(8), 1036–1045.
Gershon, J. (2002). A meta-analytic review of gender differences in ADHD. Journal of Attention Disorders, 5(3), 143–154.
Gillberg, C., & Coleman, M. (2000). The biology of the autistic syndromes (3rd ed.). London: Cambridge University Press.
Gray, K. M., & Tonge, B. J. (2005). Screening for autism in infants and preschool children with developmental delay. Australian and New Zealand Journal of Psychiatry, 39(5), 378–386.
Koyama, T., Kamio, Y., Inada, N., & Kurita, H. (2009). Sex differences in WISC-III profiles of children with high-functioning pervasive developmental disorders. Journal of Autism and Developmental Disorders, 39(1), 135–141.
Koyama, T., Tachimori, H., Osada, H., Takeda, T., & Kurita, H. (2007). Cognitive and symptom profiles in Asperger’s syndrome and high-functioning autism. Psychiatry and Clinical Neurosciences, 61(1), 99–104.
Logan, G. D. (1994). On the ability to inhibit thought and action: A users’ guide to the stop-signal paradigm. In D. Dagenbach & T. H. Carr (Eds.), Inhibitory processes in attention, memory, and language. San Diego: Academic Press.
Lord, C., Schopler, E., & Revicki, D. (1982). Sex differences in autism. Journal of Autism and Developmental Disorders, 12(4), 317–330.
McLennan, J. D., Lord, C., & Schopler, E. (1993). Sex differences in higher functioning people with autism. Journal of Autism and Developmental Disorders, 23(2), 217–227.
Nigg, J. T. (2000). On inhibition/disinhibition in developmental psychopathology: Views from cognitive and personality psychology and a working inhibition taxonomy. Psychological Bulletin, 126, 220–246.
Nyden, A., Hjelmquist, E., & Gillberg, C. (2000). Autism spectrum and attention-deficit disorders in girls. Some neuropsychological aspects. European Child and Adolescent Psychiatry, 9(3), 180–185.
Ozonoff, S., & Strayer, D. L. (1997). Inhibitory function in non-retarded children with autism. Journal of Autism and Developmental Disorders, 27(1), 59–77.
Pilowsky, T., Yirmiya, N., Shulman, C., & Dover, R. (1998). The Autism diagnostic interview-revised and the childhood Autism rating scale: Differences between diagnostic systems and comparison between genders. Journal of Autism and Developmental Disorders, 28(2), 143–151.
Thompson, T., Caruso, M., & Ellerbeck, K. (2003). Sex matters in autism and other developmental disabilities. Journal of Intellectual Disabilities, 7(4), 345–362.
Tsai, L. Y., & Beisler, J. M. (1983). The development of sex differences in infantile autism. British Journal of Psychiatry, 142, 373–378.
Volkmar, F., Chawarska, K., & Klin, A. (2005). Autism in infancy and early childhood. Annual Review of Psychology, 56, 315–336.
Volkmar, F. R., Szatmari, P., & Sparrow, S. S. (1993). Sex differences in pervasive developmental disorders. Journal of Autism and Developmental Disorders, 23(4), 579–591.
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Lemon, J.M., Gargaro, B., Enticott, P.G. et al. Brief Report: Executive Functioning in Autism Spectrum Disorders: A Gender Comparison of Response Inhibition. J Autism Dev Disord 41, 352–356 (2011). https://doi.org/10.1007/s10803-010-1039-2
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DOI: https://doi.org/10.1007/s10803-010-1039-2