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Different striatal dopamine D2 receptor occupancy in alcohol dependent patients with or without physical withdrawal symptoms – a study using IBZM-SPECT

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Summary.

Ten male patients with type I alcohol dependency fulfilling DSM-IV criteria for alcohol dependency were investigated twice using IBZM-SPECT after alcohol withdrawal (day 2 and day 28 after withdrawal). Five patients had a history of physical withdrawal symptoms, 5 patients had no such history. The group with physical withdrawal symptoms showed higher IBZM binding in both scans indicating differences of dopaminergic neurotransmission in different subtypes of alcohol dependency.

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Authors and Affiliations

  1. Department of Psychiatry and Psychotherapy (DE, TK, LTvE, BH, CL) and Department of Nuclear Medicine (FJ), University of Freiburg, Federal Republic of Germany, , , , , , DE

    D. Ebert, T. Klein, C. Lohrmann, L. Tebartz van Elst, B. Hesslinger & F. D. Juengling

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  1. D. Ebert
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  2. T. Klein
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  3. C. Lohrmann
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  4. L. Tebartz van Elst
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  5. B. Hesslinger
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  6. F. D. Juengling
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Received December 21, 2001; accepted March 18, 2002 Published online June 28, 2002

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Ebert, D., Klein, T., Lohrmann, C. et al. Different striatal dopamine D2 receptor occupancy in alcohol dependent patients with or without physical withdrawal symptoms – a study using IBZM-SPECT. J Neural Transm 109, 1215–1219 (2002). https://doi.org/10.1007/s00702-002-0749-9

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  • DOI: https://doi.org/10.1007/s00702-002-0749-9

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