NEWS RELEASE: In print Cell by Cell Press — CRI's Hoxhaj Lab has discovered tumor growth fueled by nucleotide salvage. Read more about implications for #cancer treatment: https://lnkd.in/gBazPxu9 with co-authors: Diem Tran, Ph.D., Rushendhiran Kesavan, Ph.D., & Dohun Kim, B.S. #relentlessdiscovery #womeninSTEM
Children’s Research Institute at UT Southwestern
Research Services
Dallas, Texas 1,528 followers
Relentless discovery toward the treatments of tomorrow.
About us
Children’s Medical Center Research Institute at UT Southwestern (CRI) is a nonprofit research institute built on the clinical expertise of Children’s Health System of Texas and the scientific excellence of UT Southwestern Medical Center. Under the leadership of Sean J. Morrison, Ph.D., CRI has created a world-class research and training environment that is collaborative and inclusive. We are located in the heart of Dallas, Texas, and are home to an interdisciplinary group of scientists and physicians from all over the world. Our research is focused at the intersection of stem cells, cancer, and metabolism because we believe these areas hold uncommon opportunity for discoveries that are changing the way we think about important scientific questions and yielding new strategies for treating disease.
- Website
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https://cri.utsw.edu/
External link for Children’s Research Institute at UT Southwestern
- Industry
- Research Services
- Company size
- 51-200 employees
- Headquarters
- Dallas, Texas
- Type
- Nonprofit
- Founded
- 2011
Locations
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Primary
Get directions
6000 Harry Hines Blvd
C. Kern Wildenthal Biomedical Research Building
Dallas, Texas 75235, US
Employees at Children’s Research Institute at UT Southwestern
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Tripti Sharma
Project manager | Genome Engineer | CRISPR | Disease models | Research Scientist | Transgenic Core Manager
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Michael Ortiz
Flow Cytometry Supervisor at The Children's Research Institute at UT Southwestern
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Sihan Wu 吴思涵
Assistant Professor at Children’s Research Institute at UT Southwestern
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Yoon Jung Kim
Assistant Professor, NGS core and Wu lab at Children’s Medical Center Research Institute at UT Southwestern
Updates
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Collab🚨: CRI's McBrayer Lab contributed to a discovery published in Science Magazine from the Manguso Lab & Bardeesy Lab at Mass General Hospital Cancer Center that defines a new #cancer-causing mechanism associated with IDH1 mutations (the most commonly mutated metabolic gene across cancers). From Sam McBrayer, Ph.D.: "They found that IDH1 mutations repress expression and sensing of transposable viral elements in the genome that can trigger innate immune signaling in brain and liver cancers. "Drugs that inhibit IDH1 mutant enzymes can reverse this process, leading to anti-tumor immune responses. These findings provide new insights into how IDH1 mutations, as well as drugs that target these mutations, regulate cancer growth." Read it here: https://lnkd.in/gheTrga8 #relentlessdiscovery #CancerResearch
Mutant IDH1 inhibition induces dsDNA sensing to activate tumor immunity
science.org
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Children’s Research Institute at UT Southwestern reposted this
UT Southwestern is proud to be named by U.S. News & World Report as the No. 1 hospital in DFW for the eighth straight year, with the most nationally ranked specialties of any hospital in Texas. https://bit.ly/3y7j4q3
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Check out today's blog post from Cancer Research Institute (CRI) about #SarcomaAwarenessMonth, featuring comments from postdoc Md Torikul Islam, Ph.D., in the Morrison Lab. https://lnkd.in/gdhqrUEm #relentlessdiscovery
July is Sarcoma Awareness Month – Here's What You Need to Know - Cancer Research Institute
https://www.cancerresearch.org
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OUT NOW in print (ICYMI) "Journal of Pediatric Surgery:" CRI's Dr. Natasha Corbitt has developed a pilot study at Children's Health to answer: What if we could detect bile duct obstruction in infants using their poopy diapers? 💩 Dr. Corbitt continues to dig into causes of biliary atresia — a rare pediatric liver disease that affects ~1 in 12,000 U.S. infants. https://lnkd.in/g-s85HBS #pediatricsurgery #biliaryatresia #FIINDGreenInStool #relentlessdiscovery #womeninSTEM Dr. Hao Zhu
A Pilot Study for Biliary Atresia Diagnosis: Fluorescent Imaging of Indocyanine Green in Stool
jpedsurg.org
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Important research about pediatric liver disease from Dr. Hao Zhu & Dr. Natasha Corbitt highlighted in "From the Editor's Desk" in Journal of Hepatology 's July 2024 issue: https://lnkd.in/gnXNGzw8 #relentlessdiscovery #womeninSTEM
From the Editor’s Desk...
journal-of-hepatology.eu
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IN PRINT now (ICYMI) Journal of Hepatology : CRI's Dr. Hao Zhu & Dr. Natasha Corbitt continue to dig into causes of biliary atresia — a rare pediatric liver disease that affects ~1 in 12,000 U.S. infants. https://lnkd.in/d72hdwg9 #relentlessdiscovery #womeninSTEM
Pkd1l1-deficiency drives biliary atresia through ciliary dysfunction in biliary epithelial cells
journal-of-hepatology.eu
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IN PRINT today (ICYMI) in Cell Press "Cell Metabolism:" Dr. Ralph DeBerardinis, Dr. Zheng Wu & colleagues have have identified a new way to disrupt lung cancer growth. Read more: https://lnkd.in/gPXbk6r6 #relentlessdiscovery
Electron transport chain inhibition increases cellular dependence on purine transport, salvage - Children's Medical Center Research Institute (CRI) | Dallas Texas
cri.utsw.edu
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Congrats to CRI's Garcia-Bermudez lab for their American Cancer Society Research Scholar award to test whether blocking tumor glycosaminoglycans could result in new #cancer therapies that target metastasizing, lipoprotein-hungry tumors. #relentlessdiscovery
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🎧 at 22:19 for highlights about CRI's Dr. Prashant Mishra's discovery of a beneficial metabolic INFLEXIBILITY because it only permits healthy liver cells to regenerate (recently published in Science Magazine) Listen here: https://lnkd.in/ghu76dca #relentlessdiscovery
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